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Platelet-derived growth factor receptor independent proliferation of human glioblastoma cells: selective tyrosine kinase inhibitors lack antiproliferative activity.

Gross, Dietmar and Bernhardt, Günther and Buschauer, Armin (2006) Platelet-derived growth factor receptor independent proliferation of human glioblastoma cells: selective tyrosine kinase inhibitors lack antiproliferative activity. Journal of Cancer Research and Clinical Oncology 132 (9), pp. 589-599.

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Other URL: http://www.springerlink.com/content/l063gw013kk814w4/


Abstract

PURPOSE: The aim of this study was to investigate the role of platelet-derived growth factor (PDGF) and PDGF receptors (PDGFRs) in the proliferation of human glioblastoma cells as a prerequisite for a new therapeutic approach to the treatment of malignant brain tumors with selective tyrosine kinase inhibitors such as imatinib. METHODS AND RESULTS: In the human glioblastoma cell lines U-87 MG, ...

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Item Type:Article
Date:2006
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
16736141PubMed ID
10.1007/s00432-006-0109-5DOI
Keywords:Platelet-derived growth factor receptor - Human glioblastoma cells - Imatinib
Subjects:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:21 Feb 2008 08:37
Last Modified:05 Aug 2009 13:42
Item ID:3386
Owner Only: item control page
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