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NPY Y_1 antagonists: structure-activity relationships of arginine derivatives and hybrid compounds with arpromidine-like partial structures

Aiglstorfer, Iris and Uffrecht, Anka and Geßele, K. and Moser, Christiane and Schuster, Andreas and Merz, S. and Malawska, B. and Bernhardt, Günther and Dove, Stefan and Buschauer, Armin (1998) NPY Y_1 antagonists: structure-activity relationships of arginine derivatives and hybrid compounds with arpromidine-like partial structures. Regul. Pept. 75, pp. 75-76.

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Abstract

Previously, omega-guanidino- and omega-aminoalkanamides, structurally derived from arpromidine-like histamine H2 receptor agonists, were reported as novel neuropeptide Y Y1 antagonists. Regardless of the backbone, they resemble BIBP 3226, an argininamide with high NPY Y1 receptor affinity and selectivity, with respect to nature and arrangement of the 'terminal' diaryl, guanidine, and ...

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Item Type:Article
Date:1998
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
9802389PubMed ID
Subjects:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:22 Feb 2008 13:10
Last Modified:05 Aug 2009 13:42
Item ID:3415
Owner Only: item control page
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