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Antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,1,2,2-tetraalkyl-1,2 -diphenylethanes

Hartmann, Rolf W. and Kranzfelder, Gerhard and Angerer, Erwin von and Schönenberger, Helmut (1980) Antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,1,2,2-tetraalkyl-1,2 -diphenylethanes. Journal of medicinal chemistry 23 (8), pp. 841-8.

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Abstract

Among the newly synthesized 1,1,2,2-tetraalkyl-1,2-diphenylethanes, 1,1,2,2-tetramethyl-1,2-bis(4'-hydroxyphenyl)ethane (23) and 1,1,2,2-tetramethyl-1,2-bis(3'-hydroxyphenyl)ethane (26) were the most active compounds regarding estradiol receptor affinity, exhibiting Ka values of 0.73 X 10(8) and 0.67 X 10(8) M-1, respectively. In vivo, 23 and 26 showed only very small uterotrophic activity in the ...

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Item Type:Article
Date:1980
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
7401112PubMed ID
Classification:
NotationType
AnimalsMESH
CattleMESH
Estradiol/metabolismMESH
Estradiol Congeners/chemical synthesisMESH
Estrogen Antagonists/chemical synthesisMESH
Ethane/analogs & derivativesMESH
FemaleMESH
Mammary Neoplasms, Experimental/drug therapyMESH
MiceMESH
Organ Size/drug effectsMESH
RatsMESH
Receptors, Estrogen/metabolismMESH
Uterus/drug effectsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:11 Dec 2008 15:23
Last Modified:19 Aug 2010 12:20
Item ID:4711
Owner Only: item control page
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