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The tumor-inhibiting effect of diethylstilbestrol-3,4-oxide

Schneider, M. R. and Kranzfelder, G. and Angerer, E. von and Schönenberger, H. and Metzler, M. and Michel, R. T. and Fortmeyer, H. P. and Ruckdeschel, G. (1981) The tumor-inhibiting effect of diethylstilbestrol-3,4-oxide. Journal of cancer research and clinical oncology 100 (3), pp. 247-254.

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Abstract

Diethylstilbestrol-3,4-oxide, (DES-3,4-oxide), one of the possible cancerogenic metabolites of the well-known estrogen diethylstilbestrol (DES), is a potential estrophilic cytostatic compound. It shows a very good affinity to the estrogen receptor. The uterotrophic activity determined in the mouse uterine weight bioassay is nearly identical with that of DES. Potential alkylating properties could ...

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Item Type:Article
Date:1981
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
6792206PubMed ID
Classification:
NotationType
9,10-Dimethyl-1,2-benzanthraceneMESH
AnimalsMESH
Benz(a)AnthracenesMESH
Body Weight/drug effectsMESH
Diethylstilbestrol/analogs & derivativesMESH
FemaleMESH
HumansMESH
MaleMESH
Mammary Neoplasms, Experimental/chemically inducedMESH
MiceMESH
Mice, NudeMESH
Neoplasms, Hormone-Dependent/chemically inducedMESH
Organ Size/drug effectsMESH
RatsMESH
UterusMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:03 Dec 2008 15:42
Last Modified:19 Aug 2010 12:17
Item ID:4715
Owner Only: item control page
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