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3,4-bis(3'-hydroxyphenyl)hexane--a new mammary tumor-inhibiting compound

Kranzfelder, G. and Hartmann, R. W. and Angerer, E. von and Schönenberger, H. and Bogden, A. E. (1982) 3,4-bis(3'-hydroxyphenyl)hexane--a new mammary tumor-inhibiting compound. Journal of cancer research and clinical oncology 103 (2), pp. 165-180.

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Abstract

The syntheses of the hexestrol derivatives 3,4-bis-(3'-hydroxyphenyl)hexane (4a), 3,4-bis(4'-fluoro-3'-hydroxyphenyl)hexane (4b), 3,4-bis(3',4'dihydroxyphenyl)hexane (4c), and 3,4-bis(3',4'-diacetoxyphenyl)hexane (4d) are described. All compounds showed a marked, competitive inhibition of the estradiol receptor interaction (Ka4c greater than Ka4a greater than Ka4d greater than Ka4b). Evaluated in ...

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Item Type:Article
Date:1982
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
6284766PubMed ID
Classification:
NotationType
9,10-Dimethyl-1,2-benzanthraceneMESH
AnimalsMESH
Antineoplastic Agents/chemical synthesisMESH
Breast Neoplasms/drug therapyMESH
CastrationMESH
Cell LineMESH
ChemistryMESH
FemaleMESH
Hexestrol/analogs & derivativesMESH
HumansMESH
Mammary Neoplasms, Experimental/drug therapyMESH
Neoplasms, Hormone-Dependent/drug therapyMESH
RatsMESH
Rats, Inbred StrainsMESH
Receptors, Estrogen/metabolismMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:03 Dec 2008 15:48
Last Modified:19 Aug 2010 12:14
Item ID:4716
Owner Only: item control page
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