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N,N'-Dialkyl-1,2-bis(hydroxyphenyl)ethylenediamines and N,N-dialkyl-4,5-bis(4-hydroxyphenyl)imidazolidines: syntheses and evaluation of their mammary tumor inhibiting activity

Angerer, Erwin von and Egginger, Guenter and Kranzfelder, Gerhard and Bernhauer, Horst and Schönenberger, Helmut (1982) N,N'-Dialkyl-1,2-bis(hydroxyphenyl)ethylenediamines and N,N-dialkyl-4,5-bis(4-hydroxyphenyl)imidazolidines: syntheses and evaluation of their mammary tumor inhibiting activity. Journal of medicinal chemistry 25 (7), pp. 832-837.

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Abstract

Diastereomeric N,N'-dialkyl-1,2-bis(hydroxyphenyl)ethylenediamines (5) were synthesized and tested for their affinity for the estradiol receptor. Only the (+/-)-1,2-bis(4-hydroxyphenyl)ethylenediamines with the alkyl groups C₃H₇ [(+/-)-5c, Ka = 1.1 x 19(6))], C₄H₉ [(+/-)-5e,Ka = 3.6 x 10(6)], and C₅H₁₁ [(+/-)-5h, Ka = 2.2 x 10(6)] showed a marked affinity, which is mainly due to the (+) ...

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Item Type:Article
Date:1982
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
6809943PubMed ID
Classification:
NotationType
9,10-Dimethyl-1,2-benzanthraceneMESH
AnimalsMESH
Antineoplastic Agents/chemical synthesisMESH
Breast NeoplasmsMESH
Cell Division/drug effectsMESH
Cells, CulturedMESH
ChemistryMESH
Ethylenediamines/chemical synthesisMESH
FemaleMESH
HumansMESH
Imidazoles/chemical synthesisMESH
Mammary Neoplasms, Experimental/chemically inducedMESH
RatsMESH
Receptors, EstradiolMESH
Receptors, Estrogen/metabolismMESH
StereoisomerismMESH
Thymidine/metabolismMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:03 Nov 2008 15:23
Last Modified:19 Aug 2010 12:09
Item ID:4720
Owner Only: item control page
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