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2-Phenylindoles. Relationship between structure, estrogen receptor affinity, and mammary tumor inhibiting activity in the rat

Angerer, E. von and Prekajac, J. and Strohmeier, J. (1984) 2-Phenylindoles. Relationship between structure, estrogen receptor affinity, and mammary tumor inhibiting activity in the rat. Journal of medicinal chemistry 27 (11), pp. 1439-47.

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Abstract

A number of 2-phenylindole derivatives with one hydroxy group in the meta or para position of the phenyl ring and a second one in position 5, 6, or 7 of the indole nucleus were synthesized. In addition, different alkyl groups were introduced into positions 1 and 3 of the heterocycle. The influence of these structural variations on the binding affinity for the calf uterine estrogen receptor was ...

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Item Type:Article
Date:1984
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:DFG Projekt An 139/1
Identification Number:
ValueType
6492074PubMed ID
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents/metabolismMESH
CattleMESH
FemaleMESH
Indoles/metabolismMESH
Mammary Neoplasms, Experimental/drug therapyMESH
RatsMESH
Rats, Inbred StrainsMESH
Receptors, Estrogen/metabolismMESH
Structure-Activity RelationshipMESH
Uterus/metabolismMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:11 Dec 2008 15:31
Last Modified:05 Aug 2009 13:48
Item ID:4724
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