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The tumor-inhibiting effect of isomeric dichloro(diphenylethylenediamine)platinum(II) complexes

Wappes, B. and Jennerwein, M. and Angerer, E. von and Engel, J. and Schönenberger, H. and Brunner, H. and Schmidt, M. and Berger, M. and Schmähl, D. and Seeber, S. (1984) The tumor-inhibiting effect of isomeric dichloro(diphenylethylenediamine)platinum(II) complexes. Journal of cancer research and clinical oncology 107 (1), pp. 15-20.

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Abstract

Ring unsubstituted dichloro(diphenylethylenediamine)platinum(II) complexes show a dependence of their antitumor activity on the configuration and position of phenyl rings in ethylenediamine ligand. Dichloro(1,1-diphenylethylenediamine)platinum(II) (1d) and meso-dichloro(1,2-diphenylethylenediamine)-platinum(II) (meso-2d) have a weaker effect on the human breast-cancer cell line MDA-MB 231 and on ...

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Item Type:Article
Date:1984
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
6538199PubMed ID
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents/metabolismMESH
Breast Neoplasms/pathologyMESH
Carcinoma, Ehrlich Tumor/pathologyMESH
Cell LineMESH
Cisplatin/analogs & derivativesMESH
DNA/metabolismMESH
Dose-Response Relationship, DrugMESH
Drug Evaluation, PreclinicalMESH
FemaleMESH
HumansMESH
Leukemia/pathologyMESH
MaleMESH
MiceMESH
Mice, Inbred BALB CMESH
Neoplasm TransplantationMESH
Neoplasms/metabolismMESH
Plasmacytoma/pathologyMESH
RatsMESH
StereoisomerismMESH
Structure-Activity RelationshipMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:11 Dec 2008 15:47
Last Modified:19 Aug 2010 12:12
Item ID:4725
Owner Only: item control page
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