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The inhibitory effect of 4-chloro-2-(2,6-dichloro-4-hydroxyphenyl)-1-ethyl-6-hydroxyindole (D 15413) on estrogen-dependent mammary tumors

Angerer, E. von and Prekajac, J. and Schneider, M. R. and Berger, M. R. (1985) The inhibitory effect of 4-chloro-2-(2,6-dichloro-4-hydroxyphenyl)-1-ethyl-6-hydroxyindole (D 15413) on estrogen-dependent mammary tumors. Journal of cancer research and clinical oncology 110 (3), pp. 216-220.

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Abstract

The antineoplastic activity of 4-chloro-2-(2,6-dichloro-4-hydroxyphenyl)-1-ethyl-6-hydroxyindole (D 15413) was determined in several estrogen-dependent mammary tumor models. The growth of DMBA-induced rat mammary carcinomas was inhibited by doses ranging from 2 to 18 mg/kg. A dose of 6 X 12 mg/kg per week p.o. reduced the tumor area by 82% (control + 192%). D 15413 was also active against ...

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Item Type:Article
Date:1985
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
4077919PubMed ID
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents/pharmacologyMESH
Cell LineMESH
Estrogens/pharmacologyMESH
Indoles/pharmacologyMESH
Mammary Neoplasms, Experimental/drug therapyMESH
MiceMESH
Neoplasms, Hormone-Dependent/drug therapyMESH
RatsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:10 Dec 2008 14:59
Last Modified:05 Aug 2009 13:48
Item ID:4729
Owner Only: item control page
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