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Benzo[a]carbazole derivatives. Synthesis, estrogen receptor binding affinities, and mammary tumor inhibiting activity

Angerer, Erwin von and Prekajac, Jelica (1986) Benzo[a]carbazole derivatives. Synthesis, estrogen receptor binding affinities, and mammary tumor inhibiting activity. Journal of medicinal chemistry 29 (3), pp. 380-386.

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Abstract

A number of 11-alkylbenzo[a]carbazoles and their 5,6-dihydro derivatives with one or two hydroxy groups in the aromatic rings were synthesized and studied for their binding affinities for the estrogen receptor. Best conditions for the receptor binding are provided by one hydroxy group at C-3 and a second one at position 8 or 9. The binding affinities of the benzo[a]carbazoles are somewhat lower ...

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Item Type:Article
Date:1986
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
3950918PubMed ID
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents/chemical synthesisMESH
Carbazoles/chemical synthesisMESH
CattleMESH
Cell LineMESH
Estrogen Antagonists/chemical synthesisMESH
Estrogens, Non-Steroidal/chemical synthesisMESH
FemaleMESH
HumansMESH
Mammary Neoplasms, Experimental/drug therapyMESH
Neoplasms, Hormone-Dependent/drug therapyMESH
Organ Size/drug effectsMESH
RatsMESH
Rats, Inbred StrainsMESH
Receptors, Estrogen/metabolismMESH
Structure-Activity RelationshipMESH
Uterus/drug effectsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:14 Jan 2009 12:16
Last Modified:05 Aug 2009 13:48
Item ID:4731
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