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6,7-Dihydro-4H-indolones: synthesis and biological properties

Schiller, C. D. and Angerer, E. von and Schneider, M. R. (1991) 6,7-Dihydro-4H-indolones: synthesis and biological properties. Archiv der Pharmazie 324 (10), pp. 767-771.

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Abstract

Syntheses of 6,7-dihydro-4H-indolones 6 and 10 by a selective Birch reduction of the benzene ring of the indole system are described. The antiestrogen zindoxifene and the 2-phenylindole 2 as well as 6 and 10 were tested for their relative binding affinities at the androgen receptor as well as for antiandrogenic and estrogenic properties. Both compounds 6 and 10 showed potent indirect ...

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Item Type:Article
Date:1991
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
1805709PubMed ID
Classification:
NotationType
Androgen Antagonists/chemical synthesisMESH
AnimalsMESH
Estrogen Antagonists/chemical synthesisMESH
FemaleMESH
Indoles/chemical synthesisMESH
MaleMESH
MiceMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:03 Dec 2008 15:57
Last Modified:17 May 2010 12:48
Item ID:4750
Owner Only: item control page
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