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Estrogen platinum-diamine complexes: preparation of a non-steroidal estrogen platinum-diamine complex labeled with platinum-191 and a study of its binding to the estrogen receptor in vitro and its tissue distribution in vivo

DiZio, J. P. and Carlson, K. E. and Bannochie, C. J. and Welch, M. J. and Angerer, E. von and Katzenellenbogen, J. A. (1992) Estrogen platinum-diamine complexes: preparation of a non-steroidal estrogen platinum-diamine complex labeled with platinum-191 and a study of its binding to the estrogen receptor in vitro and its tissue distribution in vivo. The Journal of steroid biochemistry and molecular biology 42 (3-4), pp. 363-373.

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Abstract

We have prepared in radiolabeled form (platinum-191) a non-steroidal estrogen platinum-diamine complex (Pt-diamine complex) that is reported to have selective cytostatic activity in estrogen receptor positive mouse mammary tumors. We then studied the interaction of this metal radiolabeled complex with the estrogen receptor in vitro and its distribution in immature rats in vivo. The radiolabeled ...

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Item Type:Article
Date:1992
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
1606047PubMed ID
Classification:
NotationType
AnimalsMESH
Diamines/chemistryMESH
Estradiol/metabolismMESH
Estrogens, Non-Steroidal/chemistryMESH
Organoplatinum Compounds/chemistryMESH
RatsMESH
Receptors, Estrogen/metabolismMESH
Tissue DistributionMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Owner: Prof. Armin Buschauer
Deposited On:10 Dec 2008 14:44
Last Modified:05 Aug 2009 13:48
Item ID:4752
Owner Only: item control page
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