Startseite UB

6-Alkyl-12-formylindolo[2,1-a]isoquinolines. Syntheses, estrogen receptor binding affinities, and stereospecific cytostatic activity

Polossek, T. and Ambros, R. and Angerer, S. von and Brandl, G. and Mannschreck, A. and Angerer, E. von (1992) 6-Alkyl-12-formylindolo[2,1-a]isoquinolines. Syntheses, estrogen receptor binding affinities, and stereospecific cytostatic activity. Journal of Medicinal Chemistry 35 (19), pp. 3537-3547.

Full text not available from this repository.

at PubMed


Abstract

A number of 6-alkyl-12-formyl-5,6-dihydroindolol[2,1-a]isoquinolines were synthesized by the Bischler-Napieralski reaction from the respective 1-alkyl-2-(3-methoxyphenyl)ethylamines and bromo-substituted (methoxyphenyl)acetic acid chlorides followed by a second ring closure reaction involving a base-generated benzyne intermediate. The methoxy functions in positions 3 and 9 or 10 were cleaved with ...

plus


Export bibliographical data

Item Type:Article
Date:1992
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
1404234PubMed ID
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents/chemical synthesisMESH
Binding SitesMESH
CattleMESH
Computer SimulationMESH
Estrogen Antagonists/chemical synthesisMESH
FemaleMESH
Isoquinolines/chemical synthesisMESH
Mammary Neoplasms, Experimental/drug therapyMESH
MiceMESH
Models, MolecularMESH
Receptors, Estrogen/metabolismMESH
StereoisomerismMESH
Uterus/drug effectsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:14 Jan 2009 12:56
Last Modified:05 Aug 2009 13:48
Item ID:4754
Owner Only: item control page
  1. University

University Library

Publication Server

Contact person
Gernot Deinzer

Telefon 0941 943-2759
Contact