Maucher, A. and Angerer, E. von and Hampl, R. and Stárka, L. (1994) The activity of epitestosterone in hormone dependent prostate tumour models. Endocrine regulations 28 (1), pp. 23-29.
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Epitestosterone has been shown previously to counteract the testosterone activity in some experimental models. In the present study the activity of epitestosterone in an in vitro model of human LNCaP/FCS prostate cells and in vitro in Dunning R 3327-GH rat prostate carcinoma was tested. In LNCaP/FGC cells cultivated with fetal calf serum (FCS) treated with dextran-coated charcoal epitestosterone displayed rather androgenic than antiandrogenic properties, whereas the cultivation with native FCS resulted in a very weak inhibition of tumour cell growth with epitestosterone in higher concentration. The growth of Dunning R 3327-GH carcinoma of prostate was very weakly enhanced by epitestosterone alone as late as at the end of the 5-week experiment. Epitestosterone did not significantly inhibit the testosterone stimulated tumour growth.
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)|
|Subjects:||500 Science > 570 Life sciences|
500 Science > 540 Chemistry & allied sciences
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Owner:||Prof. Armin Buschauer|
|Deposited On:||03 Dec 2008 15:17|
|Last Modified:||05 Aug 2009 13:48|