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1-Carbamoylalkyl-2-phenylindoles: relationship between side chain structure and estrogen antagonism

Angerer, E. von and Biberger, C. and Holler, E. and Koop, R. and Leichtl, S. (1994) 1-Carbamoylalkyl-2-phenylindoles: relationship between side chain structure and estrogen antagonism. The Journal of Steroid Biochemistry and Molecular Biology 49 (1), pp. 51-62.

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Abstract

The 2-phenylindole system has proved to be a versatile structure for the design of potent antiestrogens, especially when functional groups have been introduced into the alkyl side chain in position 1. In analogy to steroidal structures such as ICI 164,384 a number of 2-phenylindoles with carbamoylalkyl and aminoalkyl side chains were synthesized. They bind to the calf uterine estrogen receptor ...

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Item Type:Article
Date:1994
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:DFG Projekt An 139/3
Identification Number:
ValueType
8003439PubMed ID
Classification:
NotationType
AnimalsMESH
Breast Neoplasms/metabolismMESH
Cell Division/drug effectsMESH
Estradiol/analogs & derivativesMESH
Estrogen Antagonists/chemistryMESH
FemaleMESH
Hela CellsMESH
HumansMESH
Indoles/chemistryMESH
MiceMESH
Organ Size/drug effectsMESH
Polyunsaturated AlkamidesMESH
Radioligand AssayMESH
Receptors, Estrogen/geneticsMESH
Sequence DeletionMESH
Structure-Activity RelationshipMESH
Tamoxifen/pharmacologyMESH
Trans-Activation (Genetics)MESH
Tumor Cells, CulturedMESH
Uterus/drug effectsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:03 Dec 2008 15:51
Last Modified:05 Aug 2009 13:48
Item ID:4764
Owner Only: item control page
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