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Antiestrogenic activities of 3,8-dihydroxy-6,11-dihydrobenzo[a]carbazoles with sulfur-containing side chains

Golob, T. and Biberger, C. and Walter, G. and Angerer, E. von (2000) Antiestrogenic activities of 3,8-dihydroxy-6,11-dihydrobenzo[a]carbazoles with sulfur-containing side chains. Archiv der Pharmazie 333 (9), pp. 305-311.

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Abstract

The objective of this study was to explore whether the conversion of the 2-phenylindole system into the tetracyclic benzo[a]carbazole changes the endocrine profile when the side chain structure was kept constant. Five different sulfur-containing side chains were linked to the nitrogen of the tetracycle. The biological evaluation revealed that the character of the indole derivatives remained ...

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Item Type:Article
Date:2000
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
11039187PubMed ID
10.1002/1521-4184(20009)333:9<305::AID-ARDP305>3.0.CO;2-QDOI
Classification:
NotationType
AnimalsMESH
Breast NeoplasmsMESH
Carbazoles/chemical synthesisMESH
Cell Division/drug effectsMESH
Estrogen Receptor Modulators/chemical synthesisMESH
FemaleMESH
HumansMESH
MiceMESH
Molecular StructureMESH
Organ Size/drug effectsMESH
Structure-Activity RelationshipMESH
Tumor Cells, CulturedMESH
Uterus/drug effectsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:12 Dec 2008 16:35
Last Modified:05 Aug 2009 13:48
Item ID:4775
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