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Standardized kinetic microassay to quantify differential chemosensitivity on the basis of proliferative activity

Bernhardt, Günther and Reile, Herta and Birnböck, Herbert and Spruss, Thilo and Schönenberger, Helmut (1992) Standardized kinetic microassay to quantify differential chemosensitivity on the basis of proliferative activity. Journal of cancer research and clinical oncology 118 (1), pp. 35-43.

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Abstract

Conventionally in vitro cytotoxicity assays are performed as single-end-point determinations. To compensate for the diversity of growth rates among different cell lines in this report we describe a computerized kinetic chemosensitivity assay based on quantification of biomass by staining cells with crystal violet. As a prerequisite four human breast cancer cell lines (MDA-MB-231, MCF-7, T-47-D ...

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Item Type:Article
Date:1992
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
1309532PubMed ID
Classification:
NotationType
Adenocarcinoma/drug therapyMESH
Antineoplastic Agents/pharmacologyMESH
Breast Neoplasms/drug therapyMESH
Carcinoma, Intraductal, Noninfiltrating/drug therapyMESH
Cell Division/drug effectsMESH
Cisplatin/pharmacologyMESH
Diethylstilbestrol/pharmacologyMESH
Drug Screening Assays, Antitumor/methodsMESH
FemaleMESH
Fluorouracil/pharmacologyMESH
Gentian VioletMESH
HumansMESH
KineticsMESH
Melphalan/pharmacologyMESH
Neoplasms, Hormone-Dependent/drug therapyMESH
Receptors, Estrogen/analysisMESH
Receptors, Progesterone/analysisMESH
Tumor Cells, Cultured/drug effectsMESH
Vinblastine/pharmacologyMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:12 Dec 2008 17:23
Last Modified:13 Mar 2014 18:32
Item ID:4819
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