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1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethanes--new biological response modifiers for the therapy of breast cancer. Synthesis and evaluation of estrogenic/antiestrogenic properties

Schertl, Sabine and Hartmann, Rolf W. and Batzl-Hartmann, Christine and Schlemmer, Richard and Spruß, Thilo and Bernhardt, Günther and Gust, Ronald and Schönenberger, Helmut (2001) 1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethanes--new biological response modifiers for the therapy of breast cancer. Synthesis and evaluation of estrogenic/antiestrogenic properties. Archiv der Pharmazie 334 (4), pp. 125-137.

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Abstract

[meso-1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]platinum(II) complexes (meso-1-PtLL'; L,L' = Cl or L = H2O and L' = OSO3) are highly effective towards hormone-sensitive, rodent breast cancers due to their significant estrogenic potencies. Their antitumor activities are caused by modification of the immune response. The pharmacophor of these compounds, the ...

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Item Type:Article
Date:2001
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
11382148PubMed ID
10.1002/1521-4184(200104)334:4<125::AID-ARDP125>3.0.CO;2-DDOI
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents/chemical synthesisMESH
Breast Neoplasms/drug therapyMESH
Estrogen Receptor Modulators/chemical synthesisMESH
Estrogens/chemical synthesisMESH
FemaleMESH
Immunologic Factors/chemical synthesisMESH
MiceMESH
Receptors, Estrogen/metabolismMESH
Structure-Activity RelationshipMESH
Keywords:1-(2,6-Dichloro-4-hydroxyphenyl)-2-phenylethanes; biological response modifiers; synthesis; estrogen receptor affinity; estrogenic/antiestrogenic activity
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:14 Jan 2009 13:03
Last Modified:19 Aug 2010 11:20
Item ID:4837
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