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Enzymatic Hydrolyses of Alanyl-alanine-anilides by Dipeptidyl Peptidase IV

Barth, A. and Neubert, K. and Schwarz, G. and Fischer, G. and Dove, Stefan and Franke, R. (1985) Enzymatic Hydrolyses of Alanyl-alanine-anilides by Dipeptidyl Peptidase IV. In: Seydel, J. K., (ed.) QSAR and Strategies in the Design of Bioactive Compounds - Proceedings of the 5th European Symposium on QSAR. Verlag Chemie, Weinheim, 318 - 321. ISBN 3-527-26306-3; 0-89573-433-8.

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A no. of m- and p-substituted Ala-Ala-anilides were enzymically hydrolyzed by dipeptidyl peptidase IV. The catalytic consts., log kcat, are pos. related to Hammett's s-values. In another approach, the electronic effects were represented by the components of dipole moment vectors resulting from quantum chem. calcns. Conformation anal. based on the correlation of log kcat with these parameters ...


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Item Type:Book Section
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
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Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Refereed:No, this document will not be refereed
Created at the University of Regensburg:No
Deposited On:21 Jan 2009 17:56
Last Modified:05 Aug 2009 13:49
Item ID:5390
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