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QSAR in DBH-Blocking and Hypotensive Fusaric Acid Derivatives

Dove, Stefan and Franke, R. and Oehme, P. (1984) QSAR in DBH-Blocking and Hypotensive Fusaric Acid Derivatives. In: Kuchar, M., (ed.) QSAR in Design of Bioactive Compounds - Proceedings of the First International Telesymposium on Medicinal Chemistry. J. R. Prous Int. Publ., Barcelona, 117 - 134.

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Twenty-two fusaric acid derivs. (I; R2 = H, OMe, OEt, Cl, or NO2; R1 = H, halo, alkyl, O-alkyl, CO2H, etc.) and picolinic acid [98-98-6] were tested for dopamine b-hydroxylase (DBH) [9013-38-1] inhibition in vitro as well as for their effects on blood pressure in rats; QSAR of this data was carried out using the Hansch approach. QSARs of DBH inhibition differed with the enzyme prepn. (Cu2+ ...


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Item Type:Book Section
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Deposited On:21 Jan 2009 16:43
Last Modified:05 Aug 2009 13:50
Item ID:5420
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