Dove, Stefan and Franke, R. and Oehme, P. (1984) QSAR in DBH-Blocking and Hypotensive Fusaric Acid Derivatives. In: Kuchar, M., (ed.) QSAR in Design of Bioactive Compounds - Proceedings of the First International Telesymposium on Medicinal Chemistry. J. R. Prous Int. Publ., Barcelona, 117 - 134.
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Twenty-two fusaric acid derivs. (I; R2 = H, OMe, OEt, Cl, or NO2; R1 = H, halo, alkyl, O-alkyl, CO2H, etc.) and picolinic acid [98-98-6] were tested for dopamine b-hydroxylase (DBH) [9013-38-1] inhibition in vitro as well as for their effects on blood pressure in rats; QSAR of this data was carried out using the Hansch approach. QSARs of DBH inhibition differed with the enzyme prepn. (Cu2+ ...
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|Item Type:||Book Section|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)|
|Subjects:||500 Science > 570 Life sciences|
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||No|
|Owner:||Prof. Dr. Stefan Dove|
|Deposited On:||21 Jan 2009 16:43|
|Last Modified:||05 Aug 2009 13:50|