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Estrogenic activity: An example of considering effectuation models in biological data interpretation and QSAR

Dove, Stefan and Schönenberger, Helmut (1993) Estrogenic activity: An example of considering effectuation models in biological data interpretation and QSAR. In: Wermuth, C. G., (ed.) Trends in QSAR and Molecular Modelling. ESCOM, Leiden, 554 - 555. ISBN 978-90-72199-13-3.

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Abstract

On a preliminary series of 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes and -ethenes, the interrelations of affinity (pKD on estrogen receptor from calf uterus cytosol) and activity parameters (maximal estrogenic activity emax compared to estrone = 1, the Hill coeff. nH, and pD2 = log ED50) were investigated by principal component anal., leading to some first results about the structural ...

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Item Type:Book Section
Date:1993
Additional information (public):Proceedings of the 9th European Symposium on Structure-Activity Relationships: QSAR and Molecular Modelling held from September 7-11, 1992 in Strasbourg, France
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
1994:401195Other
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:No this document will not be refereed
Created at the University of Regensburg:Yes
Owner: Prof. Dr. Stefan Dove
Deposited On:21 Jan 2009 16:28
Last Modified:19 Aug 2010 11:59
Item ID:5427
Owner Only: item control page
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