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Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity

Gust, Ronald und Bernhardt, Günther und Spruss, Thilo und Krauser, Rudolf und Koch, Marion und Schönenberger, Helmut und Bauer, Kurt-Heinz und Schertl, Sabine und Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), S. 645-653.

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Zusammenfassung

The development of a galenical formulation for poorly water sol. dichloroplatinum(II) complexes suitable for the parenteral administration in cancer chemotherapy is described. The procedure, which we elaborated for [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II) (rac-4F-PtCl2), is based on the reaction of a sol. diaquaplatinum(II) salt with sodium chloride in water in the ...

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Dokumentenart:Artikel
Datum:1995
Zusätzliche Informationen (Öffentlich):CAN 124:336 1-6 Pharmacology 163168-43-2 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (prepn., stability, and antitumor activity of parenterally administrable hydrosol of [bis(fluorophenyl)ethylenediamine]dichloroplatinum(II); 125948-98-3 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), RCT (Reactant), BIOL (Biological study), RACT (Reactant or reagent) (prepn., stability, and antitumor activity of parenterally administrable hydrosol of [bis(fluorophenyl)ethylenediamine]dichloroplatinum(II); 105990-74-7P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn., stability, and antitumor activity of parenterally administrable hydrosol of [bis(fluorophenyl)ethylenediamine]dichloroplatinum(II); 7647-14-5 (Sodium chloride); 106392-12-5 (Pluronic F 68) Role: BUU (Biological use, unclassified), BIOL (Biological study), USES (Uses) (prepn., stability, and antitumor activity of parenterally administrable hydrosol of [bis(fluorophenyl)ethylenediamine]dichloroplatinum(II)
Institutionen:Chemie und Pharmazie > Institut für Pharmazie > Entpflichtete oder im Ruhestand befindliche Professoren > Prof. Schönenberger
Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische / Medizinische Chemie II (Prof. Buschauer)
Identifikationsnummer:
WertTyp
1995:877910Andere
Stichwörter / Keywords:Pharmaceutical dosage forms (hydrosols, prepn., stability, and antitumor activity of parenterally administrable hydrosol of [bis(fluorophenyl)ethylenediamine]dichloroplatinum(II); Neoplasm inhibitors (mammary gland, prepn., stability, and antitumor activity of parenterally administrable hydrosol of [bis(fluorophenyl)ethylenediamine]dichloroplatinum(II); Mammary gland (neoplasm, inhibitors, prepn., stability, and antitumor activity of parenterally administrable hydrosol of [bis(fluorophenyl)ethylenediamine]dichloroplatinum(II); platinum complex prepn stability neoplasm inhibition; fluorophenylethylenediaminedichloroplatinum complex prepn stability neoplasm inhibition
Dewey-Dezimal-Klassifikation:500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
500 Naturwissenschaften und Mathematik > 540 Chemie
Status:Veröffentlicht
Begutachtet:Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:Zum Teil
Eingebracht am:15 Jan 2009 15:55
Zuletzt geändert:12 Okt 2010 08:32
Dokumenten-ID:5477
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