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Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

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Abstract

The development of a galenical formulation for poorly water sol. dichloroplatinum(II) complexes suitable for the parenteral administration in cancer chemotherapy is described. The procedure, which we elaborated for [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II) (rac-4F-PtCl2), is based on the reaction of a sol. diaquaplatinum(II) salt with sodium chloride in water in the ...

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Item Type:Article
Date:1995
Additional information (public):CAN 124:336 1-6 Pharmacology 163168-43-2 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (prepn., stability, and antitumor activity of parenterally administrable hydrosol of [bis(fluorophenyl)ethylenediamine]dichloroplatinum(II); 125948-98-3 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), RCT (Reactant), BIOL (Biological study), RACT (Reactant or reagent) (prepn., stability, and antitumor activity of parenterally administrable hydrosol of [bis(fluorophenyl)ethylenediamine]dichloroplatinum(II); 105990-74-7P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn., stability, and antitumor activity of parenterally administrable hydrosol of [bis(fluorophenyl)ethylenediamine]dichloroplatinum(II); 7647-14-5 (Sodium chloride); 106392-12-5 (Pluronic F 68) Role: BUU (Biological use, unclassified), BIOL (Biological study), USES (Uses) (prepn., stability, and antitumor activity of parenterally administrable hydrosol of [bis(fluorophenyl)ethylenediamine]dichloroplatinum(II)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
1995:877910Other
Keywords:Pharmaceutical dosage forms (hydrosols, prepn., stability, and antitumor activity of parenterally administrable hydrosol of [bis(fluorophenyl)ethylenediamine]dichloroplatinum(II); Neoplasm inhibitors (mammary gland, prepn., stability, and antitumor activity of parenterally administrable hydrosol of [bis(fluorophenyl)ethylenediamine]dichloroplatinum(II); Mammary gland (neoplasm, inhibitors, prepn., stability, and antitumor activity of parenterally administrable hydrosol of [bis(fluorophenyl)ethylenediamine]dichloroplatinum(II); platinum complex prepn stability neoplasm inhibition; fluorophenylethylenediaminedichloroplatinum complex prepn stability neoplasm inhibition
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Owner: Guenther Bernhardt
Deposited On:15 Jan 2009 15:55
Last Modified:12 Oct 2010 08:32
Item ID:5477
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