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Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

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Abstract

The syntheses of dichlorobis(cycloalkylamine)platinum(II) complexes with cis and trans cycloalkylamine ligands [cis-PtCl2(C3H5NH2)2 to cis-PtCl2(C8H15NH2)2 and trans-PtCl2(C7H13NH2)2 and trans-PtCl2(C8H15NH2)2 are described. The distinction between cis and trans isomers was achieved by 1H-NMR spectroscopy. The antitumor activity was detd. on the cell proliferation of the human MDA-MB-231 breast ...

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Item Type:Article
Date:1993
Additional information (public):CAN 120:132 1-3 Pharmacology 15663-27-1 (Cisplatin) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (antitumor activity of, against breast cancer, dichlorobis(cycloalkylamine)platinum complexes comparison with); 38780-35-7P; 38780-36-8P; 38780-37-9P; 38780-38-0P; 41637-13-2P; 62928-48-7P; 76647-86-4P; 151767-48-5P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. and antitumor activity of, against breast cancer cells, structure in relation to); 94157-27-4P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction with silver nitrate and potassium chloride); 2516-34-9 (Cyclobutylamine); 5452-35-7 (Cycloheptylamine); 7681-11-0 (Potassium iodide) Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with dipotassium tetrachloroplatinate); 10025-99-7 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with potassium iodide and cycloalkyl amines); 765-30-0 (Cyclopropylamine) Role: BIOL (Biological study) (reaction. of, with dipotassium tetraiodoplatinate)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie > Chair of Chemistry III - Physical Chemistry (Light and Matter) > Prof. Dr. Hartmut Yersin
Identification Number:
ValueType
1994:132Other
10.1007/BF00819526DOI
Keywords:Neoplasm inhibitors (mammary gland, dichlorobis(cycloalkylamine)platinum(II) complexes as, prepn. of, structure in relation to); Mammary gland (neoplasm, inhibitors, dichlorobis(cycloalkylamine)platinum(II) complexes as, prepn. of, structure in relation to); Molecular structure-biological activity relationship (neoplasm-inhibiting, of dichlorobis(cycloalkylamine)platinum(II) complexes); dichlorobiscycloalkylamineplatinum antitumor prepn structure; biscycloalkylamineplatinum dichloro antitumor prepn structure; platinum cycloalkylamine chloro antitumor prepn structure
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:15 Jan 2009 16:00
Last Modified:13 Mar 2014 18:31
Item ID:5480
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