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Chemosensitivity of malignant melanoma models: long-term complete remission after regional hyaluronidase/vinblastine therapy

Spruss, Thilo and Bernhardt, Günther (1996) Chemosensitivity of malignant melanoma models: long-term complete remission after regional hyaluronidase/vinblastine therapy. In: Arnold, Wolfgang, (ed.) Immunodeficient Animals: Models for Cancer Research. Contributions to Oncology, 51. UNSPECIFIED, pp. 145-150.

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Abstract

Peritumoral s.c. injection of hyaluronidase (100,000 IU/kg), followed 4 later by s.c. injection of vinblastine (0.3 mg/kg, a dose which by itself had no antitumor activity), was given to nude mice bearing various human malignant melanomas. Seven such treatments (1/wk) were performed from day 22 to day 64. On day 78, histol. examns. revealed complete cure (absence of tumor cells). At the dose ...

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Item Type:Book Section
Date:1996
Additional information (public):CAN 125:75390 1-4 Pharmacology 865-21-4 (Vinblastine) Role: BAC (Biological activity or effector, except adverse), BPR (Biological process), BSU (Biological study, unclassified), BIOL (Biological study), PROC (Process) (chemosensitivity of malignant melanoma to regional hyaluronidase/vinblastine therapy); 9001-54-1 (Hyaluronidase) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (chemosensitivity of malignant melanoma to regional hyaluronidase/vinblastine therapy)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
1996:403037Other
Keywords:Drug interactions (chemosensitivity of malignant melanoma to regional hyaluronidase/vinblastine therapy); Neoplasm inhibitors (melanoma, chemosensitivity of malignant melanoma to regional hyaluronidase/vinblastine therapy); vinblastine hyaluronidase interaction melanoma inhibition; antitumor vinblastine hyaluronidase interaction
Subjects:500 Science > 570 Life sciences
500 Science > 500 Natural sciences & mathematics
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Guenther Bernhardt
Deposited On:15 Jan 2009 15:27
Last Modified:05 Aug 2009 13:50
Item ID:5485
Owner Only: item control page
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