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A Novel Mechanism for the Modulation of the Ras-Effector Interaction by small molecules

Kalbitzer, H. R. and Spoerner, M. and Graf, T. and König, B. (2005) A Novel Mechanism for the Modulation of the Ras-Effector Interaction by small molecules. Biochem. Biophys. Res. Commun. 334, 709 – 713.

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Abstract

When proteins require different conformations for their biological function, all these functional states have to coexist simultaneously in solution. However, the corresponding Gibbs free energy differences are usually rather high and thus the conformation with lowest energy predominates in solution whereas the populations of the states with higher energy (excited states) are very small. A ...

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Item Type:Article
Date:2005
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
10.1016/j.bbrc.2005.06.144DOI
16036132PubMed ID
Keywords:Ras; 31P NMR; Anti-tumor therapy; Conformational equilibrium
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Regina Hoheisel
Deposited On:05 Mar 2009 10:54
Last Modified:09 Nov 2010 09:57
Item ID:6263
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