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Synthesis and Cannabinoid Receptor Activity of Ketoalkenes from Echinacea pallida and Non-natural Analogues

Egger, M. and Pellett, P. and Nickl, K. and Geiger, S. and Graetz, S. and Seifert, R. and Heilmann, J. and König, B. (2008) Synthesis and Cannabinoid Receptor Activity of Ketoalkenes from Echinacea pallida and Non-natural Analogues. Chem. Eur. J. 14, 10978 - 10984.

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Abstract

Despite its popularity and widespread use, the efficacy of Echinacea products remains unclear and controversial. Among the various compounds isolated from Echinacea, ketoalkenes and ketoalkenynes exclusively found in the pale purple coneflower (E. pallida) are major components of the extracts. In contrast to E. purpurea alkamides, these compounds have not been synthesized and studied for ...

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Item Type:Article
Date:2008
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Chemistry and Pharmacy > Institute of Pharmacy
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
10.1002/chem.200801579DOI
18979494 PubMed ID
Keywords:cannabinoid receptors · cross-coupling · Echinacea pallida · palladium · total synthesis
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Regina Hoheisel
Deposited On:05 Mar 2009 10:55
Last Modified:08 Nov 2010 12:31
Item ID:6300
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