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Neuropeptid Y Y1-Rezeptorantagonisten der Argininamid-Reihe: Entwicklung von Synthesemethoden an polymeren Trägern und Strategien zur Herstellung von Radioliganden

Graichen, Florian (2003) Neuropeptid Y Y1-Rezeptorantagonisten der Argininamid-Reihe: Entwicklung von Synthesemethoden an polymeren Trägern und Strategien zur Herstellung von Radioliganden. PhD, Universität Regensburg.

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Date of publication of this fulltext: 07 Aug 2003 13:09

Abstract (German)

Umfangreiche Molekülvariationen und Struktur-Wirkungs-Analysen von Neuropeptid Y-Antagonisten haben zu Argininamiden geführt, die sich von BIBP3226 ((R)-Na-Diphenylacetylarginin-(p-hydroxybenzyl)amid) ableiten, aber am Guanidin-N mit elektronenziehenden Gruppen substituiert sind. Diese 'NG-akzeptorsubstituierten' (R)-Argininamide stellen hochpotente (teilweise im Bereich 10-50 pM wirksame) ...

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Translation of the abstract (English)

Extensive structural variations and investigations of the structure-activity relationships of neuropeptide Y antagonists led to argininamides related to BIBP 3226 ((R)-Na-diphenylacetylarginine-(p-hydroxybenzyl)amide). In contrast to the latter the new compounds are substituted with electron-withdrawing groups at the guanidine-N. These NG-substituted (R)-argininamides are highly potent (active in ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:6 August 2003
Referee:Prof. Dr. Armin Buschauer
Date of exam:26 June 2002
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Keywords:Amide , Antagonist , Argininderivate , Festphasentechnik , Peptide , Rezeptor , Argininamid , Festphasensynthese , Neuropeptid Y Y1-Rezeptorantagonist , NPY , Radioligand , Argininamide , Neuropeptide Y Y1 Receptor Antagonist , NPY , Radioligand , Solid Phase Synthesis
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:10115
Owner only: item control page

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