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Evolution und Regulation von Protein-Protein Interaktionen in zwei Glutamin-Amidotransferasen aus der Biosynthese von Histidin und Tryptophan

Häger, Michaela C. (2006) Evolution und Regulation von Protein-Protein Interaktionen in zwei Glutamin-Amidotransferasen aus der Biosynthese von Histidin und Tryptophan. PhD, Universität Regensburg.

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Date of publication of this fulltext: 06 Nov 2006 07:41

Abstract (German)

Glutamin-Amidotransferasen (GATasen) sind Bi-Enzymkomplexe, bestehend aus einer Glutaminase und einer Synthase, die als Modellenzyme zur Analyse von Protein-Protein Wechselwirkungen gut geeignet sind. Die Glutaminase erzeugt durch die Hydrolyse von Glutamin Ammoniak, der am aktiven Zentrum der Synthase mit einem spezifischen Substrat zu den für die jeweilige GATase charakteristischen Produkten ...

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Translation of the abstract (English)

Glutamine amidotranferases (GATases) are bi-enzyme complexes, consisting of a synthase and a glutminase subunit, which are well suited to analyze protein-protein interactions. The glutaminase generates ammonia by hydrolyzing glutamine, which reacts at the active site of the synthase with a specific substrate to products that are characteristic of each GATase. The imidazole glycerol phosphate ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:5 November 2006
Referee:Reinhard (Prof. Dr.) Sterner
Date of exam:9 August 2005
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Reinhard Sterner
Keywords:Histidinstoffwechsel , Tryptophanstoffwechsel , Glutaminamidotransferase , Allosterische Kontrolle , Molekulare Evolution , Protein-Protein-Wechselwirkung , Thermotoga maritima , Strukturanalyse , , histidine biosynthesis, Thermotoga maritima, molecular evolution, protein-protein interaction, glutamine-amidotransferase, allosteric regulation
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:10400
Owner only: item control page

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