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Synthesis and conformational analysis of polypeptides related to the inhibitor of the DNA binding and cell differentiation Id2

Colombo, Noemi (2007) Synthesis and conformational analysis of polypeptides related to the inhibitor of the DNA binding and cell differentiation Id2. PhD, Universität Regensburg.

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Date of publication of this fulltext: 09 Jul 2007 11:54

Abstract (English)

Id proteins (Id1-4) are negative regulators of several bHLH transcription factors; the 134-residue long Id2 protein additionally interacts with the retinoblastoma protein (pRb), thus representing an interesting target for cancer therapy based on the inhibition of protein-protein interactions. This work deals with the synthesis and conformational characterization of peptides derived from point ...

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Translation of the abstract (German)

Die Id Proteine Id1-4 bilden eine Untergruppe der Helix-Loop-Helix (HLH) Proteinfamilie. Ein Teil ihrer Funktionen basiert auf der Wechselwirkung mit den zur selben Proteinfamilie gehörenden Transkriptionsfaktoren deren negative Regulatoren sie darstellen. Aber auch mit anderen Proteinen treten die Id Proteine in Wechselwirkung: so wurde mit dem Retinoblastoma Protein pRb ein Bindungspartner ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:8 July 2007
Referee:Prof. Dr. Armin Buschauer and Dr. Chiara Cabrele
Date of exam:16 January 2007
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Alumni or Retired Professors > Arbeitskreis Dr. Chiara Cabrele
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Keywords:DNS-Bindung , Inhibitorproteine , Chemische Synthese , Konformationsanalyse , Zelldifferenzierung , , peptide synthesis and characterization
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:10554
Owner only: item control page

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