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Nerve growth factor-mediated induction of choline acetyltransferase in PC12 cells: evaluation of the site of action of nerve growth factor and the involvement of lysosomal degradation products of nerve growth factor

Heumann, R., Schwab, M., Merkl, Rainer and Thoenen, H. (1984) Nerve growth factor-mediated induction of choline acetyltransferase in PC12 cells: evaluation of the site of action of nerve growth factor and the involvement of lysosomal degradation products of nerve growth factor. European Journal Of Neuroscience 4 (12), pp. 3039-3050.

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Other URL: http://www.jneurosci.org/cgi/content/abstract/4/12/3039


Abstract

In previous experiments it has been demonstrated that nerve growth factor (NGF), subsequent to its binding to specific membrane receptors, is internalized. Ultrastructurally, this internalized NGF is localized in membrane-confined compartments which ultimately fuse with lysosomes. The present experiments were designed, first, to evaluate whether a very small but functionally important portion of ...

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Item type:Article
Date:1984
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Rainer Merkl
Identification Number:
ValueType
6502222PubMed ID
Classification:
NotationType
Choline O-Acetyltransferase/metabolism*MESH
Cytoplasm/ultrastructureMESH
Lysosomes/metabolismMESH
Lysosomes/ultrastructure*MESH
Neoplasms, Experimental/ultrastructureMESH
Nerve Growth Factors/antagonists & inhibitorsMESH
Nerve Growth Factors/pharmacology*MESH
Pheochromocytoma/metabolismMESH
Pheochromocytoma/ultrastructureMESH
Keywords:Choline O-Acetyltransferase/*metabolism Cytoplasm/ultrastructure Lysosomes/metabolism/*ultrastructure Neoplasms, Experimental/ultrastructure Nerve Growth Factors/antagonists & inhibitors/*pharmacology Pheochromocytoma/metabolism/ultrastructure
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:10915
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