H2r: Identification of evolutionary important residues by means of an entropy based analysis of multiple sequence alignments

URN to cite this document:: urn:nbn:de:bvb:355-epub-109291
DOI to cite this document:: 10.5283/epub.10929

Merkl, Rainer ; Zwick, Matthias

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Date of publication of this fulltext: 18 Nov 2009 10:04

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Abstract

BACKGROUND: A multiple sequence alignment (MSA) generated for a protein can be used to characterise residues by means of a statistical analysis of single columns. In addition to the examination of individual positions, the investigation of co-variation of amino acid frequencies offers insights into function and evolution of the protein and residues. RESULTS: We introduce conn(k), a novel ...