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Probing an adhesion mutant of Dictyostelium discoideum with cDNA clones and monoclonal antibodies indicates a specific defect in the contact site A glycoprotein

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Noegel, A. ; Harloff, C. ; Hirth, P. ; Merkl, Rainer ; Modersitzki, M. ; Stadler, J. ; Weinhart, U. ; Westphal, M. ; Gerisch, G.
Date of publication of this fulltext: 16 Nov 2009 10:03


Expression of developmentally regulated membrane proteins of aggregating cells of Dictyostelium discoideum is subject to several control mechanisms. One of them involves periodic cyclic-AMP pulses as signals for gene expression. To increase the probability of selecting mutants specifically defective in the contact site A (csA) glycoprotein, one of the characteristic proteins of aggregating cells, ...


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