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Studies on the molecular interactions of collagen type XVI.
Part I: The role of collagen XVI in pathological disorders
Part II: Extablishment of a retroviral mediated gene silencing model

Ratzinger, Sabine (2009) Studies on the molecular interactions of collagen type XVI.
Part I: The role of collagen XVI in pathological disorders
Part II: Extablishment of a retroviral mediated gene silencing model.
PhD, Universität Regensburg.

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Date of publication of this fulltext: 17 Dec 2009 12:35

Abstract (English)

Molecular interactions of collagen XVI in Crohn’s disease In Crohn’s disease (CD) the stress-shield of intestinal subepithelial myofibroblasts (ISEMF), provided by intact tissue is disturbed due to inflammation and cells start with remodelling activities. This is characterized by increased numbers of collagen-producing ISEMF causing an uncontrolled, irreversible wound-healing response to the ...

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Translation of the abstract (German)

Molekulare Interaktionen von Kollagen XVI in Morbus Crohn Intaktes Gewebe repräsentiert ein Schutzschild für die darin befindlichen Zellen. In Morbus Crohn ist dieser Schutzschild durch die chronische Entzündung gestört und Zellen, allen voran, intestinale subepitheliale Myofibroblasten (ISEMF) beginnen mit Reparaturarbeiten. Die Zahl der Kollagen-produzierenden ISEMF steigt als Reaktion auf die ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:2 September 2009
Referee:Prof. Dr. Roland Seifert and Prof. Dr. Susanne Grässel and Prof. Dr. Achim Göpferich
Date of exam:27 November 2009
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Keywords:Morbus Chron , Kollagen XVI , Myofibroblasten , Integrin , Fibrillin-1 , Fokale Kontakte , Entzündung
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:11212
Owner only: item control page

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