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Design stabiler und katalytisch aktiver (beta, alpha)8-Barrel-Enzyme durch Rekombination von (beta, alpha)4-Halbbarrel-Domänen

Claren, Jörg (2009) Design stabiler und katalytisch aktiver (beta, alpha)8-Barrel-Enzyme durch Rekombination von (beta, alpha)4-Halbbarrel-Domänen. PhD, Universität Regensburg.

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Date of publication of this fulltext: 14 Jan 2010 15:26

Abstract (German)

In der vorliegenden Dissertation wurde die molekulare Evolution neuer (beta/alpha)8-Barrel Enzyme durch die Rekombination von existierenden (beta/alpha)4-Halbbarreln experimentell untersucht. Dieser Arbeit liegt das Modell zugrunde, wonach die Vielfalt heutiger (beta/alpha)8-Barrel Enzyme durch eine Reihe von Duplikationen, Fusionen und Rekombinationen aus einem gemeinsamen Vorfahren halber ...

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Translation of the abstract (English)

In this work, the molecular evolution of new (beta/alpha)8-barrel enzymes has been experimentally examined by recombining existing (beta/alpha)4 half-barrels. The thesis is based on the hypothesis that the present-day diversity of (beta/alpha)8-barrel enzymes has been generated from an ancestral (beta/alpha)4 half-barrel by a series of gene duplications, fusions and recombinations. In previous ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:17 December 2009
Referee:Prof. Dr. Reinhard Sterner
Date of exam:28 October 2008
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Reinhard Sterner
Keywords:Barrel <alpha, beta-> , molekulare Evolution , gerichtete Evolution , Rationales Design , Barrel <alpha, beta-> , molecular evolution , directed evolution , rational design
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:12143
Owner only: item control page

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