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Establishing wild-type levels of catalytic activity on natural and artificial (beta alpha)8-barrel protein scaffolds

Claren, Jörg ; Malisi, Christoph ; Höcker, Birte ; Sterner, Reinhard


The generation of high levels of new catalytic activities on natural and artificial protein scaffolds is a major goal of enzyme engineering. Here, we used random mutagenesis and selection in vivo to establish a sugar isomerisation reaction on both a natural (beta alpha)(8)-barrel enzyme and a catalytically inert chimeric (beta alpha)(8)-barrel scaffold, which was generated by the recombination of ...


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