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A rationally designed monomeric variant of anthranilate phosphoribosyltransferase from Sulfolobus solfataricus is as active as the dimeric wild-type enzyme but less thermostable.
Schwab, Thomas, Skegro, Darko, Mayans, Olga
and Sterner, Reinhard
(2008)
A rationally designed monomeric variant of anthranilate phosphoribosyltransferase from Sulfolobus solfataricus is as active as the dimeric wild-type enzyme but less thermostable.
Journal of molecular biology 376 (2), pp. 506-16.
Date of publication of this fulltext: 22 Mar 2010 07:49
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| Item type | Article | ||||||||||||||||||||||||||||||||||||||
| Journal or Publication Title | Journal of molecular biology | ||||||||||||||||||||||||||||||||||||||
| Publisher: | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | ||||||||||||||||||||||||||||||||||||||
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| Place of Publication: | LONDON | ||||||||||||||||||||||||||||||||||||||
| Volume: | 376 | ||||||||||||||||||||||||||||||||||||||
| Number of Issue or Book Chapter: | 2 | ||||||||||||||||||||||||||||||||||||||
| Page Range: | pp. 506-16 | ||||||||||||||||||||||||||||||||||||||
| Date | 2008 | ||||||||||||||||||||||||||||||||||||||
| Institutions | Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Reinhard Sterner | ||||||||||||||||||||||||||||||||||||||
| Identification Number |
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| Classification |
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| Keywords | QUINOLINIC ACID PHOSPHORIBOSYLTRANSFERASE; CRYSTAL-STRUCTURE; MYCOBACTERIUM-TUBERCULOSIS; TRIOSEPHOSPHATE ISOMERASE; OVERLAP EXTENSION; DOUBLE MUTATION; PROTEIN; STABILITY; OLIGOMERIZATION; PHOSPHORYLASE; anthranilate phosphoribosyltransferase; hyperthermophile; rational protein design; sulfolobus solfataricus; thermal stability | ||||||||||||||||||||||||||||||||||||||
| Dewey Decimal Classification | 500 Science > 570 Life sciences | ||||||||||||||||||||||||||||||||||||||
| Status | Published | ||||||||||||||||||||||||||||||||||||||
| Refereed | Yes, this version has been refereed | ||||||||||||||||||||||||||||||||||||||
| Created at the University of Regensburg | Yes | ||||||||||||||||||||||||||||||||||||||
| Item ID | 13671 |
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