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Regulation of the hetero-octameric ATP phosphoribosyl transferase complex from Thermotoga maritima by a tRNA synthetase-like subunit.

Vega, M. Cristina, Zou, Peijian, Fernandez, Francisco J., Murphy, Gavin E., Sterner, Reinhard, Popov, Alexander and Wilmanns, Matthias (2005) Regulation of the hetero-octameric ATP phosphoribosyl transferase complex from Thermotoga maritima by a tRNA synthetase-like subunit. Molecular microbiology 55 (3), pp. 675-86.

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Abstract

The molecular structure of the ATP phosphoribosyl transferase from the hyperthermophile Thermotoga maritima is composed of a 220 kDa hetero-octameric complex comprising four catalytic subunits (HisGS) and four regulatory subunits (HisZ). Steady-state kinetics indicate that only the complete octameric complex is active and non-competitively inhibited by the pathway product histidine. The rationale ...

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Item type:Article
Date:2005
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Reinhard Sterner
Identification Number:
ValueType
15660995PubMed ID
10.1111/j.1365-2958.2004.04422.xDOI
Classification:
NotationType
ATP Phosphoribosyltransferase/metabolismMESH
Amino Acid SequenceMESH
Amino Acyl-tRNA Synthetases/metabolismMESH
Binding SitesMESH
Crystallography, X-RayMESH
Gene Expression Regulation, BacterialMESH
Gene Expression Regulation, EnzymologicMESH
Histidine/metabolismMESH
Models, MolecularMESH
Molecular Sequence DataMESH
Structure-Activity RelationshipMESH
Thermotoga maritima/geneticsMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:13678
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