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Stability, catalytic versatility and evolution of the (beta alpha)(8)-barrel fold.

Höcker, Birte ; Jürgens, Catharina ; Wilmanns, Matthias ; Sterner, Reinhard



Abstract

The (beta alpha)(8)-barrel is a versatile single-domain protein fold that is adopted by a large number of enzymes. The (beta alpha)(8)-barrel fold has been used as a model to elucidate the structural basis of protein thermostability and in studies to interconvert catalytic activities or substrate specificities by rational design or directed evolution. Recently, the (beta alpha)(4)-half-barrel was identified as a possible structural subdomain.


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