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Structural evidence for evolution of the beta/alpha barrel scaffold by gene duplication and fusion.

Lang, Detlef ; Thoma, Ralf ; Henn-Sax, Martina ; Sterner, Reinhard ; Wilmanns, Matthias


The atomic structures of two proteins in the histidine biosynthesis pathway consist of beta/alpha barrels with a twofold repeat pattern. It is likely that these proteins evolved by twofold gene duplication and gene fusion from a common half-barrel ancestor. These ancestral domains are not visible as independent domains in the extant proteins but can be inferred from a combination of sequence and ...


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