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Structural evidence for evolution of the beta/alpha barrel scaffold by gene duplication and fusion.

Lang, Detlef, Thoma, Ralf, Henn-Sax, Martina, Sterner, Reinhard and Wilmanns, Matthias (2000) Structural evidence for evolution of the beta/alpha barrel scaffold by gene duplication and fusion. Science (New York, N.Y.) 289 (5484), pp. 1546-50.

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Abstract

The atomic structures of two proteins in the histidine biosynthesis pathway consist of beta/alpha barrels with a twofold repeat pattern. It is likely that these proteins evolved by twofold gene duplication and gene fusion from a common half-barrel ancestor. These ancestral domains are not visible as independent domains in the extant proteins but can be inferred from a combination of sequence and ...

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Item type:Article
Date:2000
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Reinhard Sterner
Identification Number:
ValueType
10991737PubMed ID
Classification:
NotationType
Aldose-Ketose Isomerases/metabolismMESH
Amino Acid MotifsMESH
Amino Acid SequenceMESH
Aminohydrolases/metabolismMESH
Binding SitesMESH
CatalysisMESH
Crystallography, X-RayMESH
Evolution, MolecularMESH
Gene DuplicationMESH
Histidine/biosynthesisMESH
Models, MolecularMESH
Molecular Sequence DataMESH
Protein FoldingMESH
Protein Structure, TertiaryMESH
Recombination, GeneticMESH
Sequence AlignmentMESH
Thermotoga maritima/enzymologyMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:13702
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