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Cleavage of 1-Benzyltetrahydroisoquinolines to Secondary Amines via Urethanes

Kim, W.-J., Lee, D.-U. and Wiegrebe, Wolfgang (1984) Cleavage of 1-Benzyltetrahydroisoquinolines to Secondary Amines via Urethanes. Archiv der Pharmazie 317 (5), pp. 438-442.

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Date of publication of this fulltext: 01 Jul 2010 08:56


2,2,2-Trichloroethyl chloroformate and benzyl chloroformate cleave 1-benzyl-1,2,3,4-tetrahydro- 2-methylisoquinolines of type 1 to yield tertiary stilbene urethanes of type 2 which are easily reduced or hydrogenolyzed to secondary amines. 6'-(Hydroxymethyl)-laudanosine (4) is converted by these reagents to the isochroman urethanes 11 and 12 which are split to yield the secondary amine 8 without ...


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Item type:Article
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Wiegrebe
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:15630
Owner only: item control page


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