Go to content
UR Home

Degradation of 1-Benzyl-1,2,3,4-tetrahydroisoquinolines (Laudanosine) with Ethyl chloroformate: Gedamer's Intermediate

Angerer, S. von, Eibler, E., Lee, D.-U. and Wiegrebe, Wolfgang (1989) Degradation of 1-Benzyl-1,2,3,4-tetrahydroisoquinolines (Laudanosine) with Ethyl chloroformate: Gedamer's Intermediate. Scientia Pharmaceutica (Sci. Pharm.) 57, pp. 1-6.

Download (533kB)
Date of publication of this fulltext: 08 Jul 2010 04:45


Gadamer has postulated the α-chlorobisbenzyl derivate 2a as an intermediate of the degradation of laudanosine [(-)-1] to the stilbene 3 by ethyl chloroformate. Optically active 2a is easily hydrolyzed to the corresponding carbinol 2b. The optical purity of 2b is determined via diastereomeric esters. Als Zwischenprodukt des Chlorameisensäureethylester-Abbaus von Laudanosin [(-)-)1] zum Stilben 3 ...


Export bibliographical data

Item type:Article
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Wiegrebe
Keywords:1-Benzyl-1,2,3,4-tetrahydroisoquinolines, Ethyl chloroformate, Mosher-Esters
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:15694
Owner only: item control page


Downloads per month over past year

  1. Homepage UR

University Library

Publication Server


Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons