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10-(ω-Carboxylacyl)-dithranol-Derivatives

URN to cite this document:
urn:nbn:de:bvb:355-epub-157058
DOI to cite this document:
10.5283/epub.15705
Tanzer, H. ; Seidel, M. ; Wiegrebe, Wolfgang
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Date of publication of this fulltext: 08 Jul 2010 04:50


Abstract

The title compounds are not available by hydrolysis of the pertinent esters on a preparative scale. Therefore, they were prepared by base catalyzed condensation of dicarboxylic acid dichlorides or succinic acid monobenzylesterchloride, respectively, with dithranol (1). Their ICso-values for glucose-6- phosphate dehydrogenase are lower than that of dithranol (1), whilst 10- ethyldithranol (6) and ...

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