Go to content
UR Home

Synthesis of the Preininger-Alkaloid and its Enantioselective Reduction to Macrostomine

Mahboobi, Siavosh and Wiegrebe, Wolfgang (1991) Synthesis of the Preininger-Alkaloid and its Enantioselective Reduction to Macrostomine. Archiv der Pharmazie 324, pp. 275-281.

[img]
Preview
PDF
Download (1MB)
Date of publication of this fulltext: 08 Jul 2010 05:06

Abstract

The Preininger-alkaloid, dehydro-normacrostomine (2b, Scheme 1) was synthesized starting from rac. α-acetyl-3,4-dimethoxybenzylcyanide (3) (Scheme 2). The key intermediate 4-acetyl-6,7-dimethoxy-l-(3,4-methylenedioxybenzyl) isoquinoline (11) is converted via a Mannich base to the nitrile 17 (Scheme 7) which in turn is cyclized to the Preininger-alkaloid (2b) by careful hydrogenation. - Reduction ...

plus


Export bibliographical data



Item type:Article
Date:1991
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Wiegrebe
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:15724
Owner only: item control page

Downloads

Downloads per month over past year

  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons