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Methoxy- and Acetoxy-8-oxoberbines-Synthesis, Antitumor-Activity, and Interaction with DNA

URN to cite this document:
urn:nbn:de:bvb:355-epub-157260
Weimar, C. ; Angerer, S. von ; Wiegrebe, Wolfgang
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Date of publication of this fulltext: 08 Jul 2010 05:07


Abstract

Most of the memoxy-8H-dibenzo[a,g]isoquinolin-8-ones 3a-h and their acetoxy derivatives 6a-e were synthesized by condensation of 1-oxo-1,2,3,4-tetrahydroisoquinolines 4a-c and homophthalic acid anhydrides 5a and b, ether cleavage and acetylation. These protoberberinones were tested for cytostatic activity in vitro using MDA-MB-231 mammary tumor cells and for interaction with native calf thymus ...

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