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Modification of DNA bases by anthralin and related compounds

Müller, K. ; Leukel, P. ; Mayer, K.K. ; Wiegrebe, Wolfgang


Modification of bases in calf thymus DNA by treatment with the antipsoriatic drug anthralin was studied. The products of DNA bases were identified and their yields measured by gas chromatography-mass spectrometry with selected ion monitoring. Treatment of calf thymus DNA with anthralin significantly enhanced the amount of modified bases above control levels. Purine bases were modified to products ...


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