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Modification of DNA bases by anthralin and related compounds

Müller, K., Leukel, P., Mayer, K.K. and Wiegrebe, Wolfgang (1995) Modification of DNA bases by anthralin and related compounds. Biochemical Pharmacology 49 (11), pp. 1607-1613.

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Abstract

Modification of bases in calf thymus DNA by treatment with the antipsoriatic drug anthralin was studied. The products of DNA bases were identified and their yields measured by gas chromatography-mass spectrometry with selected ion monitoring. Treatment of calf thymus DNA with anthralin significantly enhanced the amount of modified bases above control levels. Purine bases were modified to products ...

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Item type:Article
Date:1995
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Wiegrebe
Interdisciplinary Subject Network:Not selected
Identification Number:
ValueType
10.1016/0006-2952(95)00096-IDOI
Keywords:anthralin; dithranol; psoriasis; DNA; base damage; free radicals
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:15906
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