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Characterization of Glucocorticoid Binding Capacity in Human Mononuclear Lymphocytes: Increase by Metyrapone is Prevented by Dexamethasone Pretreatment

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Rupprecht, R. ; Kornhuber, J. ; Wodarz, Norbert ; Göbel, C. ; Lugauer, J. ; Sinzger, C. ; Beckmann, H. ; Riederer, P. ; Möller, O. A.
Date of publication of this fulltext: 27 Aug 2010 12:18


Autoregulation of receptor systems by their own ligands is a well established biological phenomenon. While down-regulation of the glucocorticoid binding capacity by glucocorticoids has been shown in animals and humans, data on up-regulation processes in humans are lacking. To further explore glucocorticoid receptor plasticity in relation to endogenous ligands, glucocorticoid binding parameters ...


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