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In vivo and in vitro effects of glucocorticoids on lymphocyte proliferation in man: relationship to glucocorticoid receptors

Rupprecht, R. ; Wodarz, Norbert ; Kornhuber, J. ; Schmitz, B. ; Wild, K. ; Braner, H.-U. ; Müller, O. A. ; Riederer, P.



Abstract

Interrelations between the hypothalamic-pituitary-adrenal system (HPA) and the immune system represent a well-documented biological phenomenon. While in vitro administration of glucocorticoids may inhibit concanavalin A (Con A)- and phytohemagglutinin (PHA)-induced T-cell proliferation, pokeweed mitogen (PWM)-driven B-cell mitogenesis is relatively resistant to glucocorticoids. To further explore ...

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