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Xanthohumol, a chalcon derived from hops, inhibits hepatic inflammation and fibrosis

Dorn, Christoph ; Kraus, Birgit ; Motyl, Magdalena ; Weiss, Thomas S. ; Gehrig, Manfred ; Schoelmerich, Juergen ; Heilmann, Jörg ; Hellerbrand, Claus



Abstract

Xanthohumol (XN) is a major prenylated chalcone found in hops, which is used to add bitterness and flavor to beer. In this study, we first investigated the effects of XN on hepatocytes and hepatic stellate cells (HSC), the central mediators of liver fibrogenesis. XN inhibited the activation of primary human HSC and induced apoptosis in activated HSC in vitro in a dose dependent manner (0-20 micro ...

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