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Xanthohumol, a chalcon derived from hops, inhibits hepatic inflammation and fibrosis

Dorn, Christoph , Kraus, Birgit, Motyl, Magdalena, Weiss, Thomas S., Gehrig, Manfred, Schoelmerich, Juergen, Heilmann, Jörg and Hellerbrand, Claus (2010) Xanthohumol, a chalcon derived from hops, inhibits hepatic inflammation and fibrosis. Molecular nutrition & food research 54 (Suppl.), S205-S213.

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Abstract

Xanthohumol (XN) is a major prenylated chalcone found in hops, which is used to add bitterness and flavor to beer. In this study, we first investigated the effects of XN on hepatocytes and hepatic stellate cells (HSC), the central mediators of liver fibrogenesis. XN inhibited the activation of primary human HSC and induced apoptosis in activated HSC in vitro in a dose dependent manner (0-20 micro ...

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Item type:Article
Date:2010
Additional Information (public):1 Pharmacology
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Chemistry and Pharmacy > Institute of Pharmacy > Group Clinical Pharmacy (Dr. Dorn)
Identification Number:
ValueType
2010:939101Other
10.1002/mnfr.200900314DOI
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
500 Science > 570 Life sciences
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:17250
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