| Dokumentenart: | Artikel | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | International journal of oncology | ||||||||
| Verlag: | Athen: Spandidos Publ. | ||||||||
| Band: | 36 | ||||||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 2 | ||||||||
| Seitenbereich: | S. 435-441 | ||||||||
| Datum: | 2010 | ||||||||
| Zusätzliche Informationen (Öffentlich): | CAN 153:221485 1-6 Pharmacology 6754-58-1 (Xanthohumol) Role: NPO (Natural product occurrence), PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), USES (Uses) (xanthohumol inhibited proliferation, migration and interleukin-8 expression in human hepatocellular carcinoma cell) | ||||||||
| Institutionen: | Medizin > Lehrstuhl für Innere Medizin I Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann) Chemie und Pharmazie > Institut für Pharmazie > Arbeitsgruppe Klinische Pharmazie (Dr. Dorn) | ||||||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | Cytotoxic agents (antiinflammatory xanthohumol inhibited interleukin-8 expression in human hepatocellular carcinoma cell) Carcinoma (hepatocellular xanthohumol inhibited proliferation, migration and interleukin-8 expression in human hepatocellular carcinoma cell) Liver (hepatoma xanthohumol inhibited proliferation, migration and interleukin-8 expression in human hepatocellular carcinoma cell) Antitumor agents (prenylated chalcone xanthohumol derived from Humulus lupulus inhibited proliferation, migration and interleukin-8 expression in human hepatocellular carcinoma cell) Human Humulus lupulus Natural products (xanthohumol derived from Humulus lupulus inhibited proliferation, migration and interleukin-8 expression in human hepatocellular carcinoma cell) Apoptosis (xanthohumol induced apoptosis in human hepatocellular carcinoma cell) Interleukin 8 Role: BSU (Biological study, unclassified), BIOL (Biological study) (xanthohumol inhibited interleukin-8 expression in human hepatocellular carcinoma cell) Cell migration (xanthohumol inhibited migration in human hepatocellular carcinoma cell) Transcription factor NF-kB Role: BSU (Biological study, unclassified), BIOL (Biological study) (xanthohumol inhibited nuclear factor k-B activation in human hepatocellular carcinoma cell) interleukin hepatocellular carcinoma cytotoxic xanthohumol Humulus | ||||||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 540 Chemie 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 600 Technik, Medizin, angewandte Wissenschaften > 615 Pharmazie | ||||||||
| Status: | Veröffentlicht | ||||||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||||||
| An der Universität Regensburg entstanden: | Ja | ||||||||
| Dokumenten-ID: | 17251 |
Zusammenfassung
Xanthohumol, the major prenylated chalcone found in hops, is well known to exert anti-cancer effects, but information regarding the impact on hepatocellular carcinoma (HCC) cells and potential adverse effects on non-tumorous hepatocytes is limited. Here, we show that xanthohumol at a concn. of 25 micro M induced apoptosis in two HCC cell lines (HepG2 and Huh7). Furthermore, xanthohumol repressed ...
Zusammenfassung
Xanthohumol, the major prenylated chalcone found in hops, is well known to exert anti-cancer effects, but information regarding the impact on hepatocellular carcinoma (HCC) cells and potential adverse effects on non-tumorous hepatocytes is limited. Here, we show that xanthohumol at a concn. of 25 micro M induced apoptosis in two HCC cell lines (HepG2 and Huh7). Furthermore, xanthohumol repressed proliferation and migration, as well as TNF induced NF-kB activity and interleukin-8 expression in both cell lines at even lower concns. In contrast, xanthohumol concns. up to 100 micro M did not affect viability of primary human hepatocytes in vitro. In summary, our data showed that xanthohumol can ameliorate different pro-tumorigenic mechanisms known to promote HCC progression, indicating its potential as promising therapeutic agent that selectively affects cancer cells.
Metadaten zuletzt geändert: 19 Aug 2024 10:17
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