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Regulation of mammalian membranous adenylyl cyclases by diterpenes and MANT-nucleotides

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Erdorf, Miriam
Date of publication of this fulltext: 18 Oct 2010 09:32

Abstract (English)

Mammalian adenylyl cyclases (mACs) are integral membrane proteins involved in various physiological processes. For instance, they regulate cardiac contractility and kidney function. Malfunctions or the abnormal regulation of AC isoforms cause numerous disease states such like heart failure, polycystic kidney disease (PKD), neurodegenerative diseases, or pain and drug dependency. During the past ...


Translation of the abstract (German)

Adenylylcyclasen (mACs) von Säugetieren sind integrale Membranproteine, die an diversen physiologischen Prozessen beteiligt sind. Beispielsweise regulieren sie die Kontraktilität des Herzens und die Nierenfunktion. Enzymdefekte oder abnormale Regulationen der mAC Isoformen verursachen zahlreiche Krankheitszustände wie Herzinsuffizienz, polycystische Nierenerkrankung (PKD), neurodegenerative ...


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