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Regulation of mammalian membranous adenylyl cyclases by diterpenes and MANT-nucleotides

Erdorf, Miriam (2010) Regulation of mammalian membranous adenylyl cyclases by diterpenes and MANT-nucleotides. PhD, Universität Regensburg.

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Date of publication of this fulltext: 18 Oct 2010 09:32

Abstract (English)

Mammalian adenylyl cyclases (mACs) are integral membrane proteins involved in various physiological processes. For instance, they regulate cardiac contractility and kidney function. Malfunctions or the abnormal regulation of AC isoforms cause numerous disease states such like heart failure, polycystic kidney disease (PKD), neurodegenerative diseases, or pain and drug dependency. During the past ...


Translation of the abstract (German)

Adenylylcyclasen (mACs) von Säugetieren sind integrale Membranproteine, die an diversen physiologischen Prozessen beteiligt sind. Beispielsweise regulieren sie die Kontraktilität des Herzens und die Nierenfunktion. Enzymdefekte oder abnormale Regulationen der mAC Isoformen verursachen zahlreiche Krankheitszustände wie Herzinsuffizienz, polycystische Nierenerkrankung (PKD), neurodegenerative ...


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Item type:Thesis of the University of Regensburg (PhD)
Date:18 October 2010
Referee:Prof. Dr. Roland Seifert and PD Dr. Klaus Höcherl
Date of exam:27 August 2010
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Interdisciplinary Subject Network:Not selected
Keywords:adenylyl cyclase, polycystic kidney disease, forskolin, MANT-nucleotides
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:17313
Owner only: item control page


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